ADAPTIVE MECHANISMS OF LOCAL IMMUNITY OF THE ORAL MUCOSA IN CORONAVIRUS INFECTION

Abstract

The body's defenses are determined by systemic and local factors. Local protection is provided by the integrity of the oral mucosa, the microbicidal properties of saliva and lymphoid tissue. The integrity of the oral mucosa is the best physiological barrier to infection. The protective factors of saliva are determined not only by its mechanical properties, but also depend on the biological substances dissolved in it, which can cause the lysis of foreign agents. Such substances include lysozyme, immunoglobulin A, and a large number of interleukins with bactericidal and antiviral effects. A powerful factor of local protection is the secretory IgA contained in saliva.