PROGNOSTIC VALUE OF THE SPECTRUM OF CYTOKINES AND THEIR CHANGES IN VIRAL INFECTION СOVID-19COMPLICATED BY PNEUMONIA

Abstract

The peculiarity of the immune status in viral infection is manifested in a long-term selective IgA deficiency, including in combination with a high level of IgE, a decrease in phagocytosis, and an increase in concentration. Viral infection is characterized by an increase in the level of B-lymphocytes and overproduction of IgA, IgG and IgE, as well as IL-4. Studies confirm the existence of a relationship between the concentrations of IFN-γ and IL-1β, and this relationship is direct and decreases depending on the severity of the course of viral pneumonia, which indicates violations of immunoregulatory mechanisms.The level of cytokines - IL 1β, TNF- α and IL-4 is sharply increased in patients with severe Сovid-19 complicated by pneumonia. The results obtained indicate a violation of metabolic processes and pronounced immunological changes that contribute to the development of complications of this disease.The most common development was acute respiratory failure (ARF), disseminated intravascular coagulation syndrome (DIC), infectious toxic shock (ITS), pleurisy and abscess formation. In a number of patients, damage to the lung tissue and complications against this background developed rapidly, despite intensive therapy in the intensive care unit. Key words: Viral infection, pneumonia, spectrum of cytokines,